CLM SAP Edition 15 Translation of HDL Science, Part I: Function and Metabolism


CLM SAP Edition 15 Translation of HDL Science, Part I: Function and Metabolism

Topic: Cardiology
Relevant Terms: Function And Metabolism
Primary Audience: Nurse Practitioners, Pharmacists, Physician Assistants, physicians, registered dietitians, Registered Nurses
Launch Date: 28-May-12
Credits: AMA PRA Category 1 Credits
3 ACPE contact hours
3 ANCC contact hours
3 CDR continuing professional education units
Expiration Date: The accreditation for this activity has expired.

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Evaluate the role of HDL-C in reducing cardiovascular events and rates of atherosclerotic disease progression;
  2. Describe the mechanisms involved in the production, metabolism, and functionality of HDL including how they relate to atherogenesis;
  3. Identify the genetic causes of low and high serum HDL-C as well as the clinical and research implications of these genetic disorders;
  4. Explain current research defining the mechanisms underlying cholesteryl ester transfer protein (CETP) inhibition and its impact on HDL metabolism;
  5. Review the role of HDL subfractions and apolipoproteins as risk factors


    See Faculty section below for a complete list of faculty.
    Criteria for Success
    Statements of credit will be awarded based on the participant's attendance and submission of the activity evaluation form. No partial credit awarded for ACPE credit. A statement of credit will be available for download upon completion of the online evaluation/claimed credit form. In order to receive credit, participants should complete the online course, score at least 30% on the post-test, and submit the evaluation. If you have questions about this CME/CE activity, please contact the NLA at

    The National Lipid Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The National Lipid Association designates this enduring activity for a maximum of 3.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
    NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME.

    CE credit provided by AKH Inc., Advancing Knowledge in Healthcare
    AKH Inc. is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. AKH Inc. approves this APPLICATION - based activity for 3 contact hour(s) (0.3 CEUs). UAN 0077-9999-12-022-H04-P. Initial Release May 28, 2012.

    AKH Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's COA.
    AKH Inc. designates this educational activity for 3 contact hours. Accreditation applies solely to educational activities and does not imply approval or endorsement of any commercial product by the ANCC-COA.

    AKH Inc. is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR). Registered dietitians (RDs) and dietetic technicians, registered (DTRs) will receive 3 continuing professional education units (CPEUs) for completion of this program/material. CDR Accredited Provider #AN008. The focus of this activity is rated Level 2. Learners may submit evaluations of program/materials quality to the CDR at

    Disclosure Declaration
    It is the policy of NLA and AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are resolved by AKH prior to accreditation of the activity and may include any of or combination of the following: attestation to non-commercial content; notification of independent and certified CME/CE expectations; referral to National Faculty Initiative training; restriction of topic area or content; restriction to discussion of science only; amendment of content to eliminate discussion of device or technique; use of other faculty for discussion of recommendations; independent review against criteria ensuring evidence support recommendation; moderator review; and peer review. AKH/NLA planners and reviewers have no relevant financial relationships to disclose.

    Commercial Support
    There is no commercial support for this activity.

    Michael H. Davidson, MD, FNLA *
    Clinical Professor
    Director of Preventive Cardiology
    The University of Chicago Pritzker School of Medicine
    Chicago, IL

    Margo A. Denke, MD*
    Clinical Professor
    University of Texas Health Science Center
    San Antonio, TX

    Jay W. Heinecke, MD
    Professor of Medicine
    University of Washington
    Seattle, WA

    Dante S. LaRocca, PhD
    Professional Evaluation, Inc. (PEI)

    Robert S. Rosenson, MD, FNLA*
    Professor of Medicine
    Mount Sinai School of Medicine
    Cardiometabolic Disorders
    Mount Sinai Heart
    New York, NY

    Peter P. Toth, MD, PhD, FNLA*
    Director of Preventive Cardiology
    Sterling Rock Falls Clinic, Ltd.
    Chief of Medicine, CGH Medical Center
    Sterling, Illinois
    Clinical Professor
    University of Illinois School of Medicine
    Peoria, IL

    *Denotes Diplomate, American Board of Clinical Lipidology

    Faculty Disclosures

    Michael H. Davidson, MD
    Board of Directors: Direct to Consumer MD (DTC MD); Omthera Pharmaceuticals, Inc.; Professional Evaluation, Inc.; Sonogene, LLC
    Consultant: Abbott Laboratories, Inc.; Aegerion Pharmaceuticals, Inc.; Amgen; AstraZeneca; Atherotech, Inc.; Daiichi Sankyo, Inc.; Direct to Consumer MD (DTC MD); Esperion Therapeutics, Inc.; GlaxoSmithKline; Intelligent Medical Decisions, Inc. (iMD); KineMed, Inc.; LipoScience, Inc.; Merck & Co., Inc.; Novo Nordisk; Roche Pharmaceuticals; Sanofi-aventis; Synarc, Inc.; Takeda Pharmaceuticals North America, Inc.; Vindico Medical Education
    Contracted Research: Abbott Laboratories, Inc.; Daiichi Sankyo, Inc.; GlaxoSmithKline; Merck & Co., Inc.; Roche Pharmaceuticals
    Speakers Bureau: Abbott Laboratories, Inc.; GlaxoSmithKline; Merck & Co., Inc.
    Margo A. Denke, MD
    Advisory Board: Merck/Schering-Plough Pharmaceuticals, Inc.
    Jay W. Heinecke, MD
    Consultant: Amgen; Bristol-Myers Squibb; Corcept Therapeutics; GlaxoSmithKline; Insilicos LLC; Merck & Co., Inc.
    Contracted Research: Merck & Co., Inc.
    Royalties: Cleveland HeartLab, LLC
    Speakers Bureau: Merck/Schering-Plough Pharmaceuticals, Inc.
    Stockholder: Insilicos LLC
    Dante S. LaRocca, PhD
    Nothing to Disclose
    Robert S. Rosenson, MD
    Advisory Board: Abbott Laboratories, Inc.; Amgen; Genentech; Grain Foods Foundation; LipoScience, Inc.; Sanofi-aventis; Sticares InterACT
    Contracted Research: Amgen; Genentech; LipoScience, Inc.; Roche Pharmaceuticals
    Stockholder: LipoScience, Inc.
    Peter P. Toth, MD, PhD
    Consultant: Abbott Laboratories, Inc.; Amgen; Amylin Pharmaceuticals; AstraZeneca; Kowa Pharmaceuticals America, Inc.; Merck & Co., Inc.
    Speakers Bureau: Abbott Laboratories, Inc.; AstraZeneca; Boehringer Ingelheim; GlaxoSmithKline; Merck & Co., Inc.; Pfizer Inc.; Takeda Pharmaceuticals North America, Inc.

    NLA Staff
    Nothing to Disclose

    AKH Staff
    Nothing to Disclose

    Disclosure of Unlabeled Use and Investigational Product
    This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
    This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. NLA, AKH Inc., the author(s) and the publisher specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through reader's misunderstanding of the content.

    System Requirements
    To view this educational activity you will need one of the following web browsers: Google Chrome for Windows, Mac, or Linux; Internet Explorer 7.0+ for Windows; Mozilla 1.4+ for Windows, Mac, or Linux; Firefox 3.5+ for Windows, Mac, or Linux; or Safari 4.0+ for Mac.