HDL Functionality Video Interview

Title:

HDL Functionality Video Interview

Topic: Cardiology
Relevant Terms: HDL Functionality
Primary Audience: Cardiologists; Physicians; Clinicians; Specialist Health Care Providers
Launch Date: 26-Sep-12
Credits: AMA PRA Category 1 Credits
Expiration Date: The accreditation for this activity has expired.

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Discuss the role of HDL in macrophage-derived cholesterol efflux and the primary anti-atherosclerotic function of HDL particles
  2. Describe the multiple proteins associated with HDL particles and their putative role in mediating the antioxidant, anti-inflammatory, and immunological functions associated with HDL particles
  3. Discuss the effects of the acute phase response on HDL particles and the implications for its functionality and potential relevance in acute coronary syndromes
  4. List the available and potential laboratory and clinical measures of HDL functionality

    Faculty

    H. Bryan Brewer, Jr., MD, FNLA
    Director, Washington Cardiovascular Associates
    Senior Research Consultant
    Lipoprotein and Atherosclerosis Research
    MedStar Research Institute
    Washington Hospital Center
    Washington, DC
    Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Director, Cardiometabolic Disorders
    Mount Sinai Heart
    Professor of Medicine
    Mount Sinai School of Medicine
    New York, New York
    Benjamin J. Ansell, MD, FACC, FACP, FNLA
    Professor of Medicine, Division of Cardiology
    Co-Director, Cholesterol, Hypertension and
    Atherosclerosis Management Program (CHAMP)
    UCLA School of Medicine
    Los Angeles, California

    Philip Barter, MD, PhD
    Director, The Heart Research Institute
    Professor of Medicine, University of Sydney
    Sydney, Australia

    M. John Chapman, BSc, PhD, DSc, FACC
    Director, Dyslipidemia, Inflammation and
    Atherosclerosis Research Unit of the National
    Institute of Health and Medical Research (INSERM)
    Pitié and Salpêtrière University Hospital
    President, European Atherosclerosis Society
    Paris, France
    Jay W. Heinecke, MD
    Professor, Department of Medicine
    Division of Metabolism, Endocrinology and Nutrition
    Karasinski Chair in Metabolic Research
    University of Washington School of Medicine
    Seattle, Washington

    Nancy R. Webb, PhD
    Professor of Medicine
    University of Kentucky
    Lexington, Kentucky

    Welcome! Please review the following CME information for this activity and click "Proceed to Course" to enter the activity.
     
    Release date: September 2012
    Expiration date: September 2013
    Estimated time to complete activity: 2 hours
    System requirements: For PC and Macintosh users, any modern web browser that supports Flash is required to view the video content for this activity. High-speed Internet access also is recommended. This activity can also be viewed with iOS devices (iPhones, iPads).
     
    Target Audience
    This activity has been designed to meet the educational needs of cardiologists and other physicians, clinicians, and heath care providers involved in the treatment of patients with lipid disorders and cardiovascular disease.
     
    Program Overview
    In this activity, expert faculty members present their perspectives and provide an update on the emerging science and the potential clinical application of important research being conducted in the area of HDL functionality. The discussions will impart novel insight into the involvement of HDL in human pathophysiology and explore some of the areas for future research and development in this field.
     
    Program Agenda
    The HDL Functionality Video Interview Activity is a part of the Academy for the Advancement of HDL Science continuing educational series.
     
    This activity consists of a brief activity overview, followed by five video interviews, in which experts in the cardiovascular field explore emerging science and the potential clinical application of important research being conducted in the area of HDL functionality. The following topics are discussed:
     
    • Introduction
      Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    • Proteomics Analysis of HDL Subclasses and Associated HDL Function
      M. John Chapman, BSc, PhD, DSc, FACC and Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    • HDL and the Acute Phase Response
      Nancy R. Webb, PhD and Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    • Oxidative Modification of HDL and Myeloperoxidase and Other Tests of HDL Antioxidant Capacity
      Jay Heinecke, MD and H. Bryan Brewer, Jr., MD
    • Intracellular Function of HDL and Endothelial Function
      Philip Barter, MD, PhD and H. Bryan Brewer, Jr., MD
    • Functional Tests for the Evaluation of Antioxidant/Anti-inflammatory Effects: Measuring Clinically Relevant HDL Anti-inflammatory Activity
      Benjamin Ansell, MD, FACC, FACP, FNLA and Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    • Conclusion
      Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Accreditation Statement
    This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Medical Education Resources (MER) and Consensus Medical Communications (CMC). MER is accredited by the ACCME to provide continuing medical education for physicians.
     
    Credit Designation
    MER designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
     
    To contact MER, please call 303-798-9682.
     
    Disclosure of Conflicts of Interest
    MER insures balance, independence, objectivity, and scientific rigor in all our educational programs. In accordance with this policy, MER identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by MER to ensure that all scientific research referred to, reported, or used in a CME activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing its learners with high-quality CME activities that promote improvements or quality in health care and not the business interest of a commercial interest.
     
    The faculty reported the following financial relationships with commercial interests whose products or services may be mentioned in this CME activity:
     
    Name of Faculty
    Reported Financial Relationship
    Benjamin Ansell, MD, FACC, FACP, FNLA
    Consulting fees from BMS, Genentech/Roche, and Pfizer and ownership interest/shareholder in Amgen and Bruin Pharma
    Philip Barter, MD, PhD
     
    Grants/research support from Merck and consulting fees from AstraZeneca, Kowa, Merck, Novartis, Pfizer, and Roche
    H. Bryan Brewer, Jr., MD
    Consulting fees from and speakers' bureau participant with AstraZeneca, Lilly, Merck, Pfizer, and Roche; ownership interest/shareholder in HDL Therapeutics and The Medicines Company; and royalty/patent holder with HDL Therapeutics
    M. John Chapman, BSc, PhD, DSc, FACC
    Grants/research support from Kowa, Merck, and Pfizer; consulting fees from AstraZeneca, Kowa, Merck, and Pfizer; and speakers' bureau participant with Kowa and Merck
    Jay Heinecke, MD
     
    Grants/research support from BMS, GlaxoSmithKline, Merck, and Pfizer; consulting fees from Corcept and Merck; and speakers' bureau participant with Merck
    Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Grants/research support from Amgen, Genentech, Roche, and Sanofi Aventis; consulting fees from Abbott Laboratories, Amgen, Genentech, LipoScience, Roche, and Sanofi Aventis; and ownership interest/shareholder in LipoScience
    Nancy R. Webb, PhD
    No financial relationship to disclose
     
     
    The content managers reported the following financial relationships with commercial interests whose products or services may be mentioned in this CME activity:
    Name of Content Manager
    Reported Financial Relationship
    Jennifer Frederick, PharmD, BCPS
    No financial relationships to disclose
    Victoria Smith, MD
    No financial relationships to disclose
     
    Method of Participation
    There are no fees for participating in and receiving CME credit for this activity. During the period September 2012 through September 2013, participants must 1) read the learning objectives and faculty disclosures, 2) study the educational activity, 3) complete the posttest, and 4) complete the evaluation form.
     
    A statement of credit will be issued only upon electronic submission of a completed activity evaluation form and a completed posttest with a score of 70% or better. Statements of credit should be printed online upon completion of the activity via the NLA website.
     
    Media
    Internet
     
    Disclaimer
    The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of MER, CMC, or Genentech. The authors have disclosed if there is any discussion of published and/or investigational uses of agents that are not indicated by the FDA in their presentations. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of MER, CMC, and Genentech. Before prescribing any medicine, primary references and full prescribing information should be consulted. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities. The information presented in this activity is not meant to serve as a guideline for patient management.
     
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    This activity is jointly sponsored by Medical Education Resources and Consensus Medical Communications.


    Commercial Support
    This activity is supported by an educational grant from Genentech.