Cholesterol Efflux Self-Study Slide Library


Cholesterol Efflux Self-Study Slide Library

Topic: Cardiology
Relevant Terms: Cholesterol
Primary Audience: Cardiologists; Physicians; Clinicians; Specialist Health Care Providers
Launch Date: 26-Sep-12
Credits: AMA PRA Category 1 Credits
Expiration Date: The accreditation for this activity has expired.

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Describe current concepts of reverse cholesterol transport (RCT) and how this process impacts total body cholesterol
  2. Explain the proposed role and importance of HDL particles in mediating RCT
  3. Describe the molecular mechanisms involved in cholesterol efflux from arterial macrophages
  4. Discuss the role of atherosclerosis imaging for evaluating plaque composition and assisting in coronary event risk assessment.


    Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Director, Cardiometabolic Disorders
    Mount Sinai Heart
    Professor of Medicine
    Mount Sinai School of Medicine
    New York, New York
    H. Bryan Brewer, Jr., MD, FNLA
    Director, Washington Cardiovascular Associates 
    Senior Research Consultant 
    Lipoprotein and Atherosclerosis Research 
    MedStar Research Institute 
    Washington Hospital Center 
    Washington, DC
    Welcome! Please review the following CME information for this activity and click "Continue" to enter the activity.

    CME Information
    Release date:
    September 2012
    Expiration date: September 2013
    Estimated time to complete activity: 2 hours
    System requirements: Any modern web browser that supports Flash is required to view the video content for this activity. High-speed Internet access also is recommended. This activity cannot be viewed with iOS devices (iPhones, iPads) at this time.
    Target Audience
    This activity has been designed to meet the educational needs of cardiologists and other physicians, clinicians, and specialist heath care providers involved in the treatment of patients with lipid disorders and cardiovascular disease.
    Program Overview
    Designed for cardiologists involved in research or tasked with taking care of patients at risk for cardiovascular events, these slides and accompanying notes provide a comprehensive review of cholesterol efflux and the pathophysiological mechanisms regulating reverse cholesterol transport (RCT). The scientific data contributing to the current understanding of the role of high density lipoproteins (HDLs) and their related properties in maintaining cholesterol balance is discussed as well as the influence of HDLs on the development of atherosclerosis. The most recent understanding on the role of specific components and steps involved in RCT, such as ABCA1, ABCG1, SR-BI, and the associated enzymes, are summarized. Additionally, the potential role of imaging to identify high-risk or vulnerable plaques and the burden of atherosclerotic disease also is discussed.

    Program Agenda
    The Cholesterol Efflux Self-Study Activity is a part of the Academy for the Advancement of HDL Science continuing educational series.
    Chair: Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Co-chair: H. Bryan Brewer, Jr., MD
    This activity consists of a brief video overview and didactic slides organized into 3 topical chapters, primarily focusing on HDL Structure and Reverse Cholesterol, Human Models, and Imaging Studies. Slides with notes will be accessible as printable PDFs to further learning.
    Accreditation Statement
    This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Medical Education Resources (MER) and Consensus Medical Communications (CMC). MER is accredited by the ACCME to provide continuing medical education for physicians.
    Credit Designation
    Medical Education Resources designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
    To contact Medical Education Resources, please call 303-798-9682.
    Disclosure of Conflicts of Interest
    Medical Education Resources insures balance, independence, objectivity, and scientific rigor in all our educational programs. In accordance with this policy, MER identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by MER to ensure that all scientific research referred to, reported, or used in a CME activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing its learners with high-quality CME activities that promote improvements or quality in health care and not the business interest of a commercial interest.

    The faculty reported the following financial relationships with commercial interests whose products or services may be mentioned in this CME activity:

    Name of Faculty
    Reported Financial Relationship
    Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Grants/research support from Amgen, Genentech, Roche, and Sanofi Aventis; consulting fees from Abbott Laboratories, Amgen, Genentech, LipoScience, Roche, and Sanofi Aventis; and ownership interest/shareholder in LipoScience
    H. Bryan Brewer, Jr., MD
    Consulting fees from and speakers' bureau participant with AstraZeneca, Lilly, Merck, Pfizer, and Roche; ownership interest/shareholder in HDL Therapeutics and The Medicines Company; and royalty/patent holder with HDL Therapeutics

    The content managers reported the following financial relationships with commercial interests whose products or services may be mentioned in this CME activity:

    Name of Content Manager
    Reported Financial Relationship
    William Doutré, PharmD
    No financial relationships to disclose
    Victoria Smith, MD
    No financial relationships to disclose
    Method of Participation
    There are no fees for participating in and receiving CME credit for this activity. During the period September 2012 through September 2013, participants must 1) read the learning objectives and faculty disclosures, 2) study the educational activity, 3) complete the posttest, and 4) complete the evaluation form.
    A statement of credit will be issued only upon electronic submission of a completed activity evaluation form and a completed posttest with a score of 70% or better. Statements of credit should be printed online upon completion via the NLA website.




    The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of Medical Education Resources (MER), Consensus Medical Communications (CMC), or Genentech. The authors have disclosed if there is any discussion of published and/or investigational uses of agents that are not indicated by the FDA in their presentations. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of MER, CMC, and Genentech. Before prescribing any medicine, primary references and full prescribing information should be consulted. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities. The information presented in this activity is not meant to serve as a guideline for patient management.

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    This activity is jointly sponsored by Medical Education Resources and Consensus Medical Communications.

    Commercial Support
    This activity is supported by an educational grant from Genentech.