HDL Functionality Self-Study Slide Library


HDL Functionality Self-Study Slide Library

Topic: Cardiology
Relevant Terms: HDL Functionality
Primary Audience: Cardiologists; Physicians; Clinicians; Specialist Health Care Providers
Launch Date: 28-Sep-12
Credits: AMA PRA Category 1 Credits
Expiration Date: The accreditation for this activity has expired.

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Discuss the role of HDL in macrophage-derived cholesterol efflux and the primary anti-atherosclerotic function of HDL particles
  2. Describe the multiple proteins associated with HDL particles and their putative role in mediating the antioxidant, anti-inflammatory, and immunological functions associated with HDL particles
  3. Discuss the effects of the acute phase response on HDL particles and the implications for its functionality and potential relevance in acute coronary syndromes
  4. List the available and potential laboratory and clinical measures of HDL functionality


    Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Director, Cardiometabolic Disorders
    Mount Sinai Heart
    Professor of Medicine
    Mount Sinai School of Medicine
    New York, New York
    H. Bryan Brewer, Jr., MD, FNLA
    Director, Washington Cardiovascular Associates 
    Senior Research Consultant 
    Lipoprotein and Atherosclerosis Research 
    MedStar Research Institute 
    Washington Hospital Center 
    Washington, DC
    Welcome! Please review the following CME information for this activity and click "Proceed to Course" to enter the activity.
    CME Information
    Release date: September 2012
    Expiration date: September 2013
    Estimated time to complete activity: 2.0 hours
    System requirements: A modern web browser is required to view the video  and slide content for this activity. High-speed Internet access also is recommended. This activity CAN be viewed with iOS devices (iPhones, iPads).
    Target Audience
    This activity has been designed to meet the educational needs of cardiologists and other physicians, clinicians, and heath care providers involved in the treatment of patients with lipid disorders and cardiovascular disease.
    Program Overview
    In this activity, a comprehensive evaluation of the scientific data regarding the specific role and functionality of HDL and respective subspecies in the cardiovascular disease process will be detailed and summarized. The slide library and speaker notes will impart novel insights into the involvement of HDL and identify possible areas for future research related to the functionality and impact of these HDL subpopulations and their respective cardioprotective or atherogenic properties.
    Program Agenda
    The HDL Functionality Self-Study Activity is a part of the Academy for the Advancement of HDL Science continuing educational series.
    Chair: Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Co-chair: H. Bryan Brewer, Jr., MD
    This activity consists of a brief video overview and didactic slides that provide a comprehensive evaluation of the scientific data regarding HDL functionality and the role of HDL in disease processes. Slides with notes will be accessible as printable PDFs to further learning.
    Accreditation Statement
    This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Medical Education Resources (MER) and Consensus Medical Communications (CMC). MER is accredited by the ACCME to provide continuing medical education for physicians.
    Credit Designation
    MER designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
    To contact MER, please call 303-798-9682.
    Disclosure of Conflicts of Interest
    Medical Education Resources insures balance, independence, objectivity, and scientific rigor in all our educational programs. In accordance with this policy, MER identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by MER to ensure that all scientific research referred to, reported, or used in a CME activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing its learners with high-quality CME activities that promote improvements or quality in health care and not the business interest of a commercial interest.
    The faculty reported the following financial relationships with commercial interests whose products or services may be mentioned in this CME activity:
    Name of Faculty
    Reported Financial Relationship
    Robert S. Rosenson, MD, FACC, FAHA, FACP, FNLA
    Grants/research support from Amgen, Genentech, Roche, and Sanofi Aventis; consulting fees from Abbott Laboratories, Amgen, Genentech, LipoScience, Roche, and Sanofi Aventis; and ownership interest/shareholder in LipoScience
    H. Bryan Brewer, Jr., MD
    Consulting fees from and speakers' bureau participant with AstraZeneca, Lilly, Merck, Pfizer, and Roche; ownership interest/shareholder in HDL Therapeutics and The Medicines Company; and royalty/patent holder with HDL Therapeutics
    The content managers reported the following financial relationships with commercial interests whose products or services may be mentioned in this CME activity:
    Name of Content Manager
    Reported Financial Relationship
    William Doutré, PharmD
    No financial relationships to disclose
    Victoria Smith, MD
    No financial relationships to disclose

    Method of Participation
    There are no fees for participating in and receiving CME credit for this activity. During the period September 2012 through September 2013, participants must 1) read the learning objectives and faculty disclosures, 2) study the educational activity, 3) complete the posttest, and 4) complete the evaluation form.
    A statement of credit will be issued only upon electronic submission of a completed activity evaluation form and a completed posttest with a score of 70% or better. Statements of credit should be printed online upon completion via the NLA website.


    The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of MER, CMC, or Genentech. The authors have disclosed if there is any discussion of published and/or investigational uses of agents that are not indicated by the FDA in their presentations. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of MER, CMC, and Genentech. Before prescribing any medicine, primary references and full prescribing information should be consulted. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities. The information presented in this activity is not meant to serve as a guideline for patient management.
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    This activity is jointly sponsored by Medical Education Resources and Consensus Medical Communications.

    Commercial Support
    This activity is supported by an educational grant from Genentech.