CLM-SAP 16: Hypertriglyceridemia - Diagnosis, Pathophysiology, Clinical Significance and Treatment


CLM-SAP 16: Hypertriglyceridemia - Diagnosis, Pathophysiology, Clinical Significance and Treatment

Topic: Cardiology
Relevant Terms: Hypertriglyceridemia
Primary Audience: Cardiologists, Cardiovascular Nurses, Endocrinologists, Family Practitioners, Internists, Lipidologists, Lipid Specialists, Nephrologists, Nurse Practitioners, Pharmacists and Dietitians, PhDs, physicians assistants, Primary Care Physicians
Launch Date: 01-Oct-14
Credits: AMA PRA Category 1 Credits
3 ACPE contact hours
3 ANCC contact hours
3 CDR continuing professional education units
Expiration Date: The accreditation for this activity has expired.

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Describe normal triglyceride physiology and pathophysiology 
  2. Identify genetic and acquired disorders associated with hypertriglyceridemia 
  3. Recognize the value of non-HDL-C in the diagnosis and treatment of triglyceride disorders 
  4. Define treatment goals for patients with hypertriglyceridemia based on the most currently available guidelines, integrating results of clinical trials into comprehensive management strategies 
  5. Describe pharmacologic and non-pharmacologic (diet and lifestyle modification) therapies used for the treatment of dyslipidemia and the management of hypertriglyceridemia 
  6. Identify the relationship between serum triglyceride levels and risk for atherosclerotic cardiovascular disease 
  7. Describe gender and ethnic differences in the clinical presentation of hypertriglyceridemia 
  8. Define diagnostic criteria for type II diabetes and the association of insulin resistance to the development of dyslipidemia and cardiovascular disease 
  9. Discuss the potential benefits of gastric bypass surgery in patients who are obese with other co-morbid conditions 
  10. Discuss the management of hypertriglyceridemia in patients with HIV 
    Hypertriglyceridemia is associated with an increased risk of cardiovascular events and acute pancreatitis. The reduction in elevated levels of non-HDL-C, a marker of increased concentrations of circulating triglyceride-rich lipoproteins, is associated with reduced atherosclerotic cardiovascular risk. Similarly, a reduction in markedly elevated serum triglyceride levels decreases the risk of pancreatitis. This program will provide strategies to integrate evidence-based medicine into daily practice in order to appropriately assess, manage, and treat patients with hypertriglyceridemia. 
    RELEASE DATE: October 1, 2014
    EXPIRATION DATE: September 30, 2017
    ACTIVITY FORMAT: Internet activity enduring material
    In order to receive credit for this enduring program, participants must answer each question, review the ensuing critiques and evaluate the activity. To receive credit you must obtain a 70% or greater total score on your Performance Score Report. A statement of credit will be available upon completion of an evaluation form. If you have questions about this CME/ CE activity, please contact the NLA at
    For Pharmacists: Upon receipt of the completed activity evaluation form, transcript information will be available at within 4 weeks.
    NLA and AKH have structured this exercise to actively engage the participant in discovery of their knowledge, and in their ability to apply into practice through clinical vignettes/case scenarios. Once the self-assessment questions are graded, the participant has the opportunity to review their answers and critiques for each question and seek out additional information through references provided.
    Physicians who complete a program evaluation will receive a Statement of Continuing Education Credit from the NLA for up to 3 hours of AMA PRA Category 1 Credits™ toward the AMA Physician Recognition Award. 
    CME credit provided by the National Lipid Association
    The National Lipid Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
    The National Lipid Association designates this enduring activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
    Physician Assistants
    NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME.
    The National Lipid Association is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR). CDR Credentialed Practitioners will receive 3 Continuing Education Units (CPEUs) for completion of this activity. CDR Accredited Provider #NL0002.
    CE credit provided by AKH Inc., Advancing Knowledge in Healthcare
     AKH Inc., Advancing Knowledge in Healthcare is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. AKH Inc. approves this Application-based activity for 3 contact hour(s) (0.3CEUs). UAN 0077-9999-14-046-H04-P. Initial Release Date: October 1, 2014.
    AKH Inc., Advancing Knowledge in Healthcare is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.
    This activity is awarded 3 contact hours. 
    Activity is jointly-provided by AKH Inc., Advancing Knowledge in Healthcare and the National Lipid Association.
    This activity is supported by educational grants from Amarin and AstraZeneca.
    Carl E. Orringer, MD, FACC, FNLA*
    Associate Professor of Medicine
    University of Miami Miller School of Medicine
    Miami, FL
    Karen E. Aspry, MD, MS, FACC*
    Director, Lipid and Prevention Program
    Lifespan Cardiovascular Institute
    Assistant Professor of Medicine
    Alpert Medical School of Brown University
    East Greenwich, RI
    Eliot A. Brinton, MD*
    Director, Atherometabolic Research
    Utah Foundation for Biomedical Research
    Salt Lake City, UT
    Kevin C. Maki, PhD, CLS, FNLAϯ
    Chief Science Officer
    Midwest Center for Metabolic and Cardiovascular Research
    Glen Ellyn, IL
    James A. Underberg, MD, MS, FACPM, FACP, FASH, FNLA*
    Clinical Assistant Professor of Medicine
    NYU School of Medicine
    NYU Center for Prevention of Cardiovascular Disease
    Director, Bellevue Hospital Lipid Clinic
    New York, NY
    *Denotes Diplomate, American Board of Clinical Lipidology.
    †Denotes Diplomate, Accreditation Council for Clinical Lipidology.
    Karen Aspry, MD
    Merck & Co., Inc.
    Contracted Research
    Merck & Co., Inc.
    Eliot Brinton, MD
    Aegerion, Amarin, Amgen, Arisaph, AstraZeneca, Atherotech Inc., Eli Lilly & Co., Essentialis, Genzyme, Janssen Pharmaceuticals, Inc., Kowa Pharmaceuticals, Merck & Co., Inc., Novartis, Sanofi-aventis, Takeda Pharmaceuticals
    Contracted Research
    Amarin, Health Diagnostic Laboratory, Inc.,
    Aegerion, Amarin, AstraZeneca, Daiichi Sankyo, Inc., Genzyme, Janssen Pharmaceuticals, Inc., Kowa Pharmaceuticals, Merck & Co., Inc., Takeda Pharmaceuticals
    Kevin Maki, PhD
    Advisory Board
    Amarin, Omthera/ AstraZeneca, Pharmavite, LLC, Sancilio and Company, Inc., Trygg Pharmaceuticals
    Abbott/ AbbVie Laboratories, Omthera/ AstraZeneca, Pharmavite, LLC, Trygg Pharmaceuticals
    Contracted Research
    Abbott/ AbbVie Laboratories,  DSM, Omthera/ AstraZeneca,  Pharmavite, LLC, Trygg Pharmaceuticals
    Carl Orringer, MD
    Merck & Co., Inc.
    James Underberg, MD
    Advisory Board
    GlaxoSmithKline, Kowa Pharmaceuticals, Merck & Co., Inc.
    Aegerion, Amarin, AstraZeneca, Eli Lilly & Co., Genzyme, LipoScience, Inc.,  Novartis
    Contracted Research
    Speakers Bureau
    Daiichi Sankyo, Inc., GlaxoSmithKline, Kowa Pharmaceuticals, LipoScience, Inc., Merck & Co., Inc., Novartis
    Robert Wild, MD, PhD, MPH
    Disclosure Declaration
    It is the policy of the NLA and AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are resolved by AKH prior to accreditation of the activity and may include any of or combination of the following: attestation to non-commercial content; notification of independent  and certified CME/CE expectations; referral to National Faculty Initiative training; restriction of topic area or content; restriction to discussion of science only; amendment of content to eliminate discussion of device or technique; use of other faculty for discussion of recommendations; independent review against criteria ensuring evidence support recommendation; moderator review; and peer review. NLA/AKH planners and reviewers have no relevant financial relationships to disclose.
    Disclosure of Unlabeled Use and Investigational Product
    This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
    This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. NLA, AKH Inc., the author(s) and the publisher specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through reader’s misunderstanding of the content.
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